After fighting briefly in the Extreme Championship Wrestling (ECW) between 1999 and 2000, Lita signed a contract with World Wrestling Entertainment (WWE), staying there until her retirement in November 2006. In WWE she has won the Women's Championship four times and was entered in the Hall of Fame in April 2014.
Originally, she was paired with Essa Rios, but she achieved her greatest push alongside Matt and Jeff Hardy as Team Xtreme, and in 2005–2006 was a heel wrestler, including as a manager to Edge. Throughout her career, she won the WWE Women's Championship where she is an overall four time champion in WWE.
After her retirement from wrestling in 2006, she formed the punk rock band The Luchagors. The band released their self-titled debut album on September 11, 2007. On the latest edition of Women’s Wrestling Weekly, she discussed WWE not doing another Evolution PPV: “Dude, why is it not back? So Mae Young got so much positive feedback, Evolution was sold out, granted, you can’t look at your own timeline for how people feel because they’re like, ‘You’re so great,’ and I’m like, oh, everyone loved it, but from what I got, everybody responded really positively to it, even just financially, it was sold out, I don’t understand why there is not another Evolution, why it didn’t make the regular PPV cut, was really shocking to me."