Cain Ramirez Velasquez is an American professional wrestler and former mixed martial artist of Mexican descent. Between 2010 and 2011 and again between 2012 and 2015 he was the heavyweight champion of the Ultimate Fighting Championship (UFC).

In 2010, he was named Fighter of the Year by several industry magazines, including Inside MMA, MMA Live and Sherdog.

In February 2016, he would have to face Werdum again to regain the title he lost at UFC 196. On January 23, however, Velasquez had to sit out the fight with a back injury and Stipe Miocic was inserted in his place.

The following day Werdum also announced an injury, leading the UFC to temporarily cancel the event. On July 9 he faced Travis Browne at the UFC 200 event: after a few standing exchanges Velasquez managed to bring his opponent to the canvas and from this position he ended the match with the ground and pound, winning by TKO just 3 seconds from the end of the first round. With this win he earned the Performance of the Night award.

Velasquez was then scheduled to face former champion Werdum in a rematch in December 2016, but the Nevada athletic commission denied the Mexican the opportunity to fight due to some physical problems on the part of the athlete.

He returned to fight on February 17, 2019 in the first UFC event on ESPN, however he was defeated by KO after only twenty-six seconds by Francis Ngannou.