The WWE Performance Center uses former wrestlers as trainers. The inaugural head trainer was Bill DeMott, who departed the company in 2015 and was replaced by Matt Bloom. 

Other trainers include Sara Amato, Robbie Brookside, Norman Smiley, Adam Pearce, Mike Quackenbush, Scotty 2 Hotty and Sarah Stock. Dusty Rhodes was responsible for developing the trainees' microphone skills and wrestling personas until his death in 2015. The Performance Center includes some guest trainers, including Kevin Nash and Scott Hall.

In addition to training contracted performers, the Performance Center is also regularly used for tryouts which operate on an invite-only basis and include athletes from a wide variety of backgrounds, including established domestic and international professional wrestlers, amateur wrestlers, NFL and NCAA American football players, and individuals from a range of other sporting and non-sporting backgrounds.

The facility covers 26,000 square feet and includes seven training rings, a strength and conditioning program, edit and production facilities including an ultra-slow camera, and a voice-over room that performers and on-air announcers can use to practice.

 The facility was opened in 2013 and replaced the training center at WWE's former developmental territory, Florida Championship Wrestling (FCW), which was based in Tampa and had been serving as WWE's developmental headquarters since 2008.