Chyna is known for having wrestled in the World Wrestling Federation between 1997 and 2001. She began her career in the WWF as a bodyguard to Triple H, but the two soon became engaged in real life. Both were members of D-Generation X, a stable which also included several other wrestlers.

Chyna was the first WWF woman to wrestle full-time in the men's division. She was also the first woman to win a seat in the Royal Rumble, King of the Ring tournament, and compete for the WWF Championship. In 1999 she became the first and still only woman to win the Intercontinental Championship: she did it twice. She also won the Women's Championship on one occasion, before leaving the company.

The storyline with Eddie Guerrero is famous in which the latter defined her as his 'Mamacita', the couple proved to be a real success so as to become the most loved team of 2000. Chyna remembered that year with Eddie Guerrero, given the real problems with Triple H and Stephanie, as the most beautiful and carefree of his career. A great friendship was born between the two in real life that continued even after her abandonment in WWE.

In 2001, her contract was not renewed and it is believed that one of the reasons for her could also be her now ended romantic relationship with Triple H.

Outside of wrestling, Chyna was featured twice in Playboy magazine as well as numerous films and television shows. In 2005 she participated in the reality show The Surreal Life, which led her to work again for the same television network, in the spin-off The Surreal Life: Fame Games (2007) and in Celebrity Rehab with Dr. Drew (2008).

She is also known for her relationship with Sean Waltman, better known as X-Pac, and the two were also the protagonists of an amateur hard movie which was then put on sale in 2004 under the title 1 Night in China. Following the good success of the video, starting from 2011 she embarks on a real career as a porn star by starring in the film Backdoor to Chyna.

On the night between April 20 and 21, 2016, she was found dead at the age of 46 in her residence in Redondo Beach, California, lying prone on the bed with blood and foam from her nose and mouth. The autopsy gave her cause of death as an accidental overdose of tranquilizers, sleeping pills and alcohol. Her body was later cremated, and her ashes scattered in the Pacific Ocean.